The multiphase circumgalactic medium (CGM), a reservoir of missing metals, baryons, and energy, plays a key role in our understanding of galaxy evolution. However, extraordinary observational challenges make it one of the least understood components of galaxies. I will show a few snippets of our recent efforts using multi-wavelength (X-ray to radio) data: 1) Constraining chemical, thermal, and kinematic properties of the hot CGM of our Galaxy using novel spectroscopic decomposition coupled with self-consistent ionization modeling in X-ray absorption and X-ray emission, 2) Spectroscopic detection and characterization of the hot CGM of individual spiral galaxies in X-ray absorption and X-ray emission, 3) Identifying the primary determinant of the ionized CGM energetics by stacking millions of galaxies in mm, and 4) Assessing the mass and kinematics of missing accretion in the neutral CGM employing 21-cm emission spectroscopy. I will discuss how next-generation missions will bring transformative advances to the field of multiphase CGM by scaling up these studies to statistically complete surveys.